Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity

Quercetin compounds have antioxidant, anti-inflammatory and anticancer pharmacological functions. Long-term exposure to acrylamide (AA) can cause liver injury endanger human health. However, whether quercetin attenuate AA-induced the specific mechanism are not clear. Here, we studied structure-activity relationship of in reducing hepatotoxicity vivo vitro. In studies found that quercetin-like protect against by oxidative stress levels, activating AKT/mTOR signaling pathway autophagy, improving mitochondrial apoptosis endoplasmic reticulum stress-mediated apoptosis. vitro protected HepG2 cells from AA attenuating activation lowering ROS levels exerting antioxidant effects thus stress, increasing membrane potential, apoptosis-related proteins, Furthermore, conformational differences between correlated with their protective capacity hepatotoxicity, showing best due its strongest activity. conclusion, through multiple pathways autophagy apoptosis, correlates